Sindhu Chandran | Immune Tolerance Network | San Francisco, CA

Ann  & Robert H. Lurie Children's Memorial Hospital of Chicago: Pediatric  Transplantation | Chicago,IL

Emory University School of  Medicine: Transplantation | Atlanta,GA

UCSF School of  Medicine: Transplantation | San Francisco,CA

University of  Pennsylvania Medical Center: Transplantation   | Philadelphia,PA

Children’s Hospital of Pittsburgh  of UPMC Peds Transplant | Pittsburgh,PA

For organ transplant recipients, anti-rejection medications known as “immunosuppressive drugs” help prevent the immune system from attacking the foreign organ and causing damage. Although this helps keep the organ healthy, anti-rejection medications have a number of serious side effects including an increased risk of infections and certain kinds of cancer.

Some individuals who receive organ transplants are able to come off of all immune-suppressing medications without rejecting their organ. This is called “tolerance.”

The goal of the ALLTOL Study is to follow tolerant transplant recipients to learn:

• How long liver or kidney transplant recipients can remain tolerant
• What happens in the tolerant recipient’s body over time
• If there are patterns in the body that are linked to tolerance