Autoimmune diseases occur when the immune system mistakenly flags certain cells in the body as foreign invaders. The resulting attack can cause irreparable damage to critical organs and tissues. For example, in multiple sclerosis, it’s the myelin coating that insulates nerve cells; in lupus, it can be any number of organs or systems that are damaged. Currently, the primary methods to treat patients with autoimmune disease utilize immune suppressors, which help reduce the inflammatory attack on tissues but can put patients at higher risk for developing infections.
Immune tolerance therapies are designed to reprogram the immune system to stop the disease-causing immune attack on self-tissue while maintaining the immune system's ability to fight infection. The Immune Tolerance Network (ITN) is also working to identify biomarkers of immune tolerance that may help to identify the right treatment course for future patients.
This section contains a list of ITN's autoimmune clinical trials that are currently enrolling participants. To see all of ITN's active and completed studies in autoimmune disease, please visit For Researchers.
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ITN093AI
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DARE-APS
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Principal Investigator:
Doruk Erkan | Hospital for Special Surgery | New York, NY
Jason Knight | University of Michigan | Ann Arbor, MI
A study about the safety of daratumumab in patients with antiphospholipid syndrome (APS), and its effectiveness at reducing the antiphospholipid antibodies that cause APS.
Category:
Autoimmune Disease
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Specific Category:
Primary Antiphospholipid Syndrome
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Status:
Enrollment
Learn more:
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ITN091AI
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VIBRANT
)
Principal Investigator:
Maria Dall'era | University of California San Francisco | San Francisco, CA
Betty Diamond | The Feinstein Institute for Medical Research | Manhasset, NY
David Wofsy | University of California San Francisco | San Francisco, CA
The goal of the VIBRANT trial is to determine if treating lupus nephritis with VIB4920 in addition to standard therapy is more effective than treating lupus nephritis with standard therapy alone.
Category:
Autoimmune Disease
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Specific Category:
Lupus Nephritis
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Status:
Enrollment
Learn more:
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ITN080AI
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REBOOT
)
Principal Investigator:
Patrick Nachman | University of Minnesota | Minneapolis, MN
REBOOT will test whether a combination of, belimumab and rituximab, is safe and if this combination is more effective at blocking the immune attack on the kidney of patients with Primary Membranous Neuropathy (MN).
Category:
Autoimmune Disease
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Specific Category:
Autoimmune Diseases
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Status:
Enrollment
Learn more:
Principal Investigator:
Jeffrey Cohen | Cleveland Clinic | Cleveland, OH
Paolo Muraro | Imperial College London | London, England
George Georges | Fred Hutchinson Cancer Research Center | Chicago, IL
BEAT-MS is a clinical trial comparing chemotherapy followed by autologous hematopoietic stem cell transplant (AHSCT) – a type of bone marrow transplantation – to the most effective medicines regularly used to treat relapsing MS.
Category:
Autoimmune Disease
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Specific Category:
Multiple Sclerosis
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Status:
Enrollment
Learn more:
