Building on clinical trial and laboratory research insights from the past decade, the ITN has focused and deliberate strategies to achieving tolerance in each disease area. The research supported by the ITN has unlocked new therapeutic approaches and discovered new biomarkers that promise to change the way physicians treat patients. Explore ITN clinical trials below by using a search term or by sorting the specific trial categories. If you have questions or want more information about ITN clinical trials, contact us.
Principal Investigator:
Allan Kirk, MD, PhD | Duke University School of Medicine
TEACH is a clinical trial investigating whether cells from the kidney donor's bone marrow, called mesenchymal stromal cells (MSCs) will allow kidney transplant recipients to stop immunosuppressive medications.
Category:
Transplantation
|
Specific Category:
Kidney Transplantation
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Status:
Active
Learn more:
Principal Investigator:
Linda DiMeglio, MD, MPH | Indiana University and Riley Hospital for Children | Indianapolis, IN
T1DES is a clinical study for people with type 1 diabetes who were previously enrolled in an ITN clinical study.
Category:
Type 1 Diabetes
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Specific Category:
|
Status:
Active
Learn more:
Principal Investigator:
Gideon Lack | Evelina Childrens Hospital | London, UK
LEAP Trio is a follow-up to the LEAP study of early peanut consumption. LEAP Trio will investigate the durability of tolerance to peanut allergen in LEAP participants at age 12, development of peanut allergy in younger siblings of LEAP participants, and parental characteristics that may impact development of food allergy.
Category:
Allergy & Asthma
|
Specific Category:
Peanut Allergy
|
Status:
Active
Learn more:
Principal Investigator:
James Markman, MD, PhD | Massachusetts General Hospital | Boston, MA
Sandy Feng, MD, PhD | University of California San Francisco | San Francisco, CA
LITTMUS is a clinical research study testing a new approach to achieve transplant tolerance using the liver transplant recipient’s own T regulatory cells (Tregs).
Category:
Transplantation
|
Specific Category:
Liver Transplantation
|
Status:
Active
Learn more:
Principal Investigator:
David Fox, MD | University of Michigan | Ann Arbor, MI
Dinesh Khanna, MD | University of Michigan | Ann Arbor, MI
BRAVOS is a clinical trial evaluating Brentuximab Vendotin treatment for Diffuse Cutaneous Systemic Sclerosis.
Category:
Autoimmune Disease
|
Specific Category:
Scleroderma
|
Status:
Active
Learn more:
Principal Investigator:
Jeffrey Cohen, MD | Cleveland Clinic
George Georges, MD | Fred Hutchinson Cancer Research Center
Paolo Muraro, MD, PhD | Imperial College London
BEAT-MS is a clinical trial comparing chemotherapy followed by autologous hematopoietic stem cell transplant (AHSCT) – a type of bone marrow transplantation – to the most effective medicines regularly used to treat relapsing MS.
Category:
Autoimmune Disease
|
Specific Category:
Multiple Sclerosis
|
Status:
Active
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Principal Investigator:
Hugh Sampson, MD | Icahn School of Medicine at Mount Sinai | New York
Jose Clemente, PhD | Icahn Institute for Genomics and Multiscale Biology | New York
ACTIVATE is a clinical trial investigating the impact of the infant microbiome on allergy development.
Category:
Allergy & Asthma
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Specific Category:
|
Status:
Active
Learn more:
Principal Investigator:
Patrick Nachman, MD | University of Minnesota
Ignacio Sanz, MD | Emory University
REBOOT will test whether a combination of, belimumab and rituximab, is safe and if this combination is more effective at blocking the immune attack on the kidney of patients with Primary Membranous Neuropathy (MN).
Category:
Autoimmune Disease
|
Specific Category:
|
Status:
Active
Learn more:
Principal Investigator:
Stephen R. Durham, MD | Imperial College, London
GRADUATE is a clinical research trial, which will test whether a novel drug called Dupixent® given with grass pollen immunotherapy will help the immunotherapy work in a shorter treatment period and remain effective after the completion of treatment.
Category:
Allergy & Asthma
|
Specific Category:
Hayfever
|
Status:
Active
Learn more:
Principal Investigator:
Brett King, MD, PhD | Yale University
The REVEAL study will investigate whether the experimental study medication, AMG714, can bring back normal color to the skin in vitiligo.
Category:
Autoimmune Disease
|
Specific Category:
|
Status:
Active
Learn more:
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