Predicting Peanut Allergy

A follow-up paper from the Learning about Early Peanut Allergy (LEAP) was published online today in JACI-In Practice. This paper examined biomarkers of LEAP participants with “difficult to diagnose” peanut allergy (low to moderate positive peanut skin prick testing and peanut-specific IgE levels) to determine whether peanut component-specific IgE could be used to diagnose peanut allergy thus avoiding the need for an oral food challenge. The addition of the Ara h 2 component-specific IgE improved our ability to diagnose peanut allergy, although the authors note that there was a significant false negative rate of 52%.