Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells
Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G.
Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G. (2021). Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. Front Immunol, 12 (705140).
Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects
Diggins KE, Serti E, Muir VS, Rosasco M, Lu T, Balmas E, Nepom GT, Linsley PS
Diggins KE, Serti E, Muir VS, Rosasco M, Lu T, Balmas E, Nepom GT, Linsley PS (2021). Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects. JCI Insight, 6 (3), 142680.
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals
Sims EK, Bundy BN, Stier K, Serti E, Lim N, Long SA, Geyer SM, Moran A, Greenbaum CJ, Evans-Molina C, Herold KC; Type 1 Diabetes TrialNet Study Group.
Sims EK, Bundy BN, Stier K, Serti E, Lim N, Long SA, Geyer SM, Moran A, Greenbaum CJ, Evans-Molina C, Herold KC; Type 1 Diabetes TrialNet Study Group. (2021). Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals. Sci Transl Med., 13 (583).
Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes
Linsley PS, Barahmand-Pour-Whitman F, Balmas E, DeBerg HA, Flynn KJ, Hu AK, Rosasco M, Chen J, O'Rourke C, Serti E, Gersuk VH, Motwani K, Seay HR, Brusko TM, Kwok WW, Speake C, Greenbaum CJ, Nepom GT, Cerosaletti K
Linsley PS, Barahmand-Pour-Whitman F, Balmas E, DeBerg HA, Flynn KJ, Hu AK, Rosasco M, Chen J, O'Rourke C, Serti E, Gersuk VH, Motwani K, Seay HR, Brusko TM, Kwok WW, Speake C, Greenbaum CJ, Nepom GT, Cerosaletti K (2021). Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes. JCI Insight, 6 (22), e151349.
IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes
Greenbaum CJ, Serti E, Lambert K, Weiner LJ, Kanaparthi S, Lord S, Gitelman SE, Wilson DM, Gaglia JL, Griffin KJ, Russell WE, Raskin P, Moran A, Steven M. Willi, Tsalikian E, DiMeglio LA, Herold KC, Moore WV, Goland R, Harris M, Craig ME, Schatz DA, Baidal DA, Rodriguez H, Utzschneider KM, Nel HJ, Soppe CL, Boyle KD, Cerosaletti K, Keyes-Elstein L, Long SA, Thomas R, McNamara JG, Buckner JH, Sanda S, ITN058AI EXTEND Study Team
Greenbaum CJ, Serti E, Lambert K, Weiner LJ, Kanaparthi S, Lord S, Gitelman SE, Wilson DM, Gaglia JL, Griffin KJ, Russell WE, Raskin P, Moran A, Steven M. Willi, Tsalikian E, DiMeglio LA, Herold KC, Moore WV, Goland R, Harris M, Craig ME, Schatz DA, Baidal DA, Rodriguez H, Utzschneider KM, Nel HJ, Soppe CL, Boyle KD, Cerosaletti K, Keyes-Elstein L, Long SA, Thomas R, McNamara JG, Buckner JH, Sanda S, ITN058AI EXTEND Study Team (2021). IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes. JCI Insight, 6 (21), e150074.
Exhausted CD8+ T Cells linked to Alefacept response in T1D have distinct trajectories differing by KIR phenotype
Diggins KE, Serti E, Muir V, Rosasco M, Lu T, Balmas E, Nepom G, Long SA, Linsley P
Diggins KE, Serti E, Muir V, Rosasco M, Lu T, Balmas E, Nepom G, Long SA, Linsley P (2021). Exhausted CD8+ T Cells linked to Alefacept response in T1D have distinct trajectories differing by KIR phenotype. JCI Insight, e142680..
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes
Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putman AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA
Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putman AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA (2021). The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes. JCI Insight, 6 (18), e147474.
Approaches to Establishing Tolerance in Immune Mediated Diseases
Huffaker M F, Sanda S, Chung S, St. Clair EW, Nepom GT, Smilek DE
Huffaker M F, Sanda S, Chung S, St. Clair EW, Nepom GT, Smilek DE (2021). Approaches to Establishing Tolerance in Immune Mediated Diseases. Front Immunol, 12, 744804.
Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Randomized Trial Comparing Clinical and Biological Responses to Cat Allergen
Larson D, Patel P, Salapatek AM, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James E, French D, Lelic A, Larché M, Altman MC, Togias A, Durham SR
Larson D, Patel P, Salapatek AM, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James E, French D, Lelic A, Larché M, Altman MC, Togias A, Durham SR (2020). Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Randomized Trial Comparing Clinical and Biological Responses to Cat Allergen. J Allergy Clin Immunol, 145 (6), 1585-1597.
Association of Respiratory Allergy, Asthma and Expression of the SARS-CoV-2 Receptor, ACE2
Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC
Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC (2020). Association of Respiratory Allergy, Asthma and Expression of the SARS-CoV-2 Receptor, ACE2. J Allergy Clin Immunol, epub ahead of print.
Medical algorithm: Early introduction of food allergens in high-risk Populations
Fisher HR, Lack G, Roberts G, Bahnson HT, Du Toit G
Fisher HR, Lack G, Roberts G, Bahnson HT, Du Toit G (2020). Medical algorithm: Early introduction of food allergens in high-risk Populations. Allergy, 76 (5), 1592-1594.
Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance
Logan K, Du Toit G, Giovannini M, Turcanu V, Lack G
Logan K, Du Toit G, Giovannini M, Turcanu V, Lack G (2020). Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance. Annu Rev Cell Dev Biol, 36, 511-528.
Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?
Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson HT, Leung DYM, Lack G
Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson HT, Leung DYM, Lack G (2020). Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?. Allergy, 75 (9), 2185-2205.
IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE
Santos AF, Barbosa-Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O'Rourke C, Bahnson HT, Cheng H, James L, Gould HJ, Sutton BJ, Maleki SJ, Lack G
Santos AF, Barbosa-Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O'Rourke C, Bahnson HT, Cheng H, James L, Gould HJ, Sutton BJ, Maleki SJ, Lack G (2020). IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE. Allergy, 75 (9), 2309-2318.
Non-Linear Rituximab Pharmacokinetics and Complex Relationship between Rituximab Concentrations and Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in ANCA-Associated Vasculitis: The RAVE Trial Revisited
Bensalem A, Mulleman D, Paintaud G, Azzopardi N, Gouilleux-Gruart V, Cornec D, Specks U, Ternant D
Bensalem A, Mulleman D, Paintaud G, Azzopardi N, Gouilleux-Gruart V, Cornec D, Specks U, Ternant D (2020). Non-Linear Rituximab Pharmacokinetics and Complex Relationship between Rituximab Concentrations and Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in ANCA-Associated Vasculitis: The RAVE Trial Revisited. Clin Pharmacokinet., 59 (4), 519-530.
CALIBRATE: A Phase 2 Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis
Atisha-Fregoso Y, Malkiel S, Harris KM, Byron M, Ding L, Kanaparthi S, Barry WT, Gao W, Ryker K, Tosta P, Askanase AD, Boackle SA, Chatham WW, Kamen DL, Karp DR, Kirou KA, Lim SS, Marder B, McMahon M, Parikh SV, Pendergraft WF 3rd, Podoll AS, Saxena A, Wofsy D, Diamond B, Smilek DE, Aranow C, Dall'Era M
Atisha-Fregoso Y, Malkiel S, Harris KM, Byron M, Ding L, Kanaparthi S, Barry WT, Gao W, Ryker K, Tosta P, Askanase AD, Boackle SA, Chatham WW, Kamen DL, Karp DR, Kirou KA, Lim SS, Marder B, McMahon M, Parikh SV, Pendergraft WF 3rd, Podoll AS, Saxena A, Wofsy D, Diamond B, Smilek DE, Aranow C, Dall'Era M (2020). CALIBRATE: A Phase 2 Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis. Arthritis Rheumatol., 73 (1), 121-131.
Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis
Harris KM, Lim N, Lindau P, Robins H, Griffith LM, Nash RA, Turka LA, Muraro PA
Harris KM, Lim N, Lindau P, Robins H, Griffith LM, Nash RA, Turka LA, Muraro PA (2020). Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis. JCI Insight, 5 (2), e127655.
Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3 in ANCA-Associated Vasculitis
Thompson GE, Fussner LA, Hummel AM, Schroeder DR, Silva F, Snyder MR, Langford CA, Merkel PA, Monach PA, Seo P, Spiera RF, St Clair EW, Stone JH, Specks U
Thompson GE, Fussner LA, Hummel AM, Schroeder DR, Silva F, Snyder MR, Langford CA, Merkel PA, Monach PA, Seo P, Spiera RF, St Clair EW, Stone JH, Specks U (2020). Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3 in ANCA-Associated Vasculitis. Front Immunol, 11, 2053.
Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis
Owczarczyk K, Cascino M, Holweg C, Tew GW, Ortmann W, Behrens T, Schindler T, Langford CA, St Clair EW, Merkel PA, Spiera R, Seo P, Kallenberg CG, Specks U, Lim N, Stone J, Brunetta P, Prunotto M, RAVE-ITN Research Group
Owczarczyk K, Cascino M, Holweg C, Tew GW, Ortmann W, Behrens T, Schindler T, Langford CA, St Clair EW, Merkel PA, Spiera R, Seo P, Kallenberg CG, Specks U, Lim N, Stone J, Brunetta P, Prunotto M, RAVE-ITN Research Group (2020). Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis. JCI Insight, 5 (18), e136180.
Precision transplant pathology
Wood-Trageser MA, Xu Q, Zeevi A, Randhawa P, Lesniak A, Demetris AJ
Wood-Trageser MA, Xu Q, Zeevi A, Randhawa P, Lesniak A, Demetris AJ (2020). Precision transplant pathology. Curr Opin Organ Transplant, 25 (4), 412-419.
Biomarkers of severity and threshold of allergic reactions during oral peanut challenges
Santos AF, Du Toit G, O'Rourke C, Becares N, Couto-Francisco N, Radulovic S, Khaleva Ekaterina, Basting M, Harris KM, Larson D, Sayre P, Plaut M, Roberts G, Bahnson HT, Lack G
Santos AF, Du Toit G, O'Rourke C, Becares N, Couto-Francisco N, Radulovic S, Khaleva Ekaterina, Basting M, Harris KM, Larson D, Sayre P, Plaut M, Roberts G, Bahnson HT, Lack G (2020). Biomarkers of severity and threshold of allergic reactions during oral peanut challenges. J Allergy Clin Immunol, 146 (2), 344-355.
Deletion of donor-reactive T cell clones after human liver transplant
Savage TM, Shonts BA, Lau S, Obradovic A, Robins H, Shaked A, Shen Y, Sykes M
Savage TM, Shonts BA, Lau S, Obradovic A, Robins H, Shaked A, Shen Y, Sykes M (2020). Deletion of donor-reactive T cell clones after human liver transplant. Am J Transplant, 20 (2), 538-545.
Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Towards Personalized Management
Feng S, Bucuvalas JC, Mazariegos GV, Magee JC, Sanchez-Fueyo A, Spain KM, Lesniak A, Kanaparthi S, Perito ER, Venkat V, Burrell BE, Alonso EM, Bridges ND, Doo E, Gupta NA, Himes RW, Ikle D, Jackson AM, Lobritto SJ, Jose Lozano J, Martinez M, Ng VL, Rand EB, Sherker AH, Sundaram S, Turmelle YP, Wood-Trageser MA, Demetris AJ
Feng S, Bucuvalas JC, Mazariegos GV, Magee JC, Sanchez-Fueyo A, Spain KM, Lesniak A, Kanaparthi S, Perito ER, Venkat V, Burrell BE, Alonso EM, Bridges ND, Doo E, Gupta NA, Himes RW, Ikle D, Jackson AM, Lobritto SJ, Jose Lozano J, Martinez M, Ng VL, Rand EB, Sherker AH, Sundaram S, Turmelle YP, Wood-Trageser MA, Demetris AJ (2020). Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Towards Personalized Management. Hepatology, epub ahead of print.
Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus
Levitsky J, Burrell BE, Kanaparthi S, Turka LA, Kurian SM, Sanchez-Fueyo A, Lozano JJ, Demetris A, Lesniak A, Kirk AD, Stempora L, Yang G, Mathew JM
Levitsky J, Burrell BE, Kanaparthi S, Turka LA, Kurian SM, Sanchez-Fueyo A, Lozano JJ, Demetris A, Lesniak A, Kirk AD, Stempora L, Yang G, Mathew JM (2020). Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus. Hepatology, 72 (2), 569-583.
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
Wiedeman AE, Muir VS, Rosasco M, DeBerg HA, Presnell S, Haas B, Dufort MJ, Speake C, Greenbaum CJ, Serti E, Nepom GT, Blahnik G, Kus AM, James E, Linsley PS, Long SA
Wiedeman AE, Muir VS, Rosasco M, DeBerg HA, Presnell S, Haas B, Dufort MJ, Speake C, Greenbaum CJ, Serti E, Nepom GT, Blahnik G, Kus AM, James E, Linsley PS, Long SA (2020). Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression. J Clin Invest, 130 (1), 480-490.
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Chase Crawford J, Alfei F, Alli S, Pereira Ribeiro S, Castellaw AH, McGargill MA, Jin H, Boi SH, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly R, Zehn D, James E, Nepom GT, Youngblood B
Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Chase Crawford J, Alfei F, Alli S, Pereira Ribeiro S, Castellaw AH, McGargill MA, Jin H, Boi SH, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly R, Zehn D, James E, Nepom GT, Youngblood B (2020). Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes. Nat Immunol, 21 (5), 578-587.
CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes
Narsale A, Lam B, Moya R, Lu T, Mandelli A, Gotuzzo I, Pessina B, Giamporcaro G, Geoffrey R, Buchanan K, Harris M, Bergot A, Thomas R, Hessner MJ, Battaglia M, Serti E, Davies JD
Narsale A, Lam B, Moya R, Lu T, Mandelli A, Gotuzzo I, Pessina B, Giamporcaro G, Geoffrey R, Buchanan K, Harris M, Bergot A, Thomas R, Hessner MJ, Battaglia M, Serti E, Davies JD (2020). CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes. JCI Insight, 6 (2), e136114.
Stem, effector and hybrid states of memory CD8+ T cells
Lugli E, Galletti G, Boi SK, Youngblood B
Lugli E, Galletti G, Boi SK, Youngblood B (2020). Stem, effector and hybrid states of memory CD8+ T cells. Trends Immunol., 41 (1), 17-28.
The MALT1 locus and Peanut Avoidance in the Risk for Peanut Allergy
Winters A, Bahnson HT, Ruczinski I, Boorgula MP, Malley C, Keramati AR, Chavan S, Larson D, Cerosaletti K, Sayre PH, Plaut M, Du Toit G, Lack G, Barnes KC, Nepom GT, Mathias RA, Immune Tolerance Network LEAP Study Team
Winters A, Bahnson HT, Ruczinski I, Boorgula MP, Malley C, Keramati AR, Chavan S, Larson D, Cerosaletti K, Sayre PH, Plaut M, Du Toit G, Lack G, Barnes KC, Nepom GT, Mathias RA, Immune Tolerance Network LEAP Study Team (2019). The MALT1 locus and Peanut Avoidance in the Risk for Peanut Allergy. J Allergy Clin Immunol, 19, 30279.
Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity
Tsilochristou O, Du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, Bahnson HT, Radulovic S, Basting M, Plaut M, Lack G, Immune Tolerance Network LEAP Study Team
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