Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression
Habib T, Long SA, Samuels PL, Brahmandam A, Tatum M, Funk A, Hocking AM, Cerosaletti K, Mason MT, Whalen E, Rawlings DJ, Greenbaum C, Buckner JH, Type 1 Diabetes TrialNet Study Group
Associated Clinical Trial(s):
Habib T, Long SA, Samuels PL, Brahmandam A, Tatum M, Funk A, Hocking AM, Cerosaletti K, Mason MT, Whalen E, Rawlings DJ, Greenbaum C, Buckner JH, Type 1 Diabetes TrialNet Study Group (2019). Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression. Diabetes, 68(6), 1240-1250. https://doi.org/10.2337/db18-1081 PMID: 30894366. PMCID: PMC6610015.
B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes
Linsley PS, Greenbaum CJ, Speake C, Long SA, Dufort MJ
Associated Clinical Trial(s):
Linsley PS, Greenbaum CJ, Speake C, Long SA, Dufort MJ (2019). B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes. JCI Insight, 4(4). https://doi.org/10.1172/jci.insight.126136 PMID: 30830871. PMCID: PMC6478438.
Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes
Dufort MJ, Greenbaum CJ, Speake C, Linsley PS
Associated Clinical Trial(s):
Dufort MJ, Greenbaum CJ, Speake C, Linsley PS (2019). Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes. JCI Insight, 4(4). https://doi.org/10.1172/jci.insight.125556 PMID: 30830868. PMCID: PMC6478408.
T-cell exhaustion correlates with improved outcomes in kidney transplant recipients
Fribourg M, Anderson L, Fischman C, Cantarelli C, Perin L, La Manna G, Rahman A, Burrell BE, Heeger PS, Cravedi P
Associated Clinical Trial(s):
Fribourg M, Anderson L, Fischman C, Cantarelli C, Perin L, La Manna G, Rahman A, Burrell BE, Heeger PS, Cravedi P (2019). T-cell exhaustion correlates with improved outcomes in kidney transplant recipients. Kidney Int, 96(2), 436-449. https://doi.org/10.1016/j.kint.2019.01.040 PMID: 31040060. PMCID: PMC6650324.
Transplantation tolerance in nonhuman primates and humans
Sykes M, Griesemer AD
Associated Clinical Trial(s):
Sykes M, Griesemer AD (2019). Transplantation tolerance in nonhuman primates and humans. Bone Marrow Transplant, 54(Suppl 2), 815-821. https://doi.org/10.1038/s41409-019-0620-3 PMID: 31431694. PMCID: PMC7323053.
Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring
Wood-Trageser MA, Lesniak AJ, Demetris AJ
Associated Clinical Trial(s):
Wood-Trageser MA, Lesniak AJ, Demetris AJ (2019). Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring. Transplantation, 103(7), 1306-1322. https://doi.org/10.1097/TP.0000000000002656 PMID: 30768568. PMCID: PMC6594872.
Outcomes of immunosuppression minimization and withdrawal early after liver transplantation
Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch JD, Levitsky J, Reyes J, Klintmalm GB, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH
Associated Clinical Trial(s):
Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch JD, Levitsky J, Reyes J, Klintmalm GB, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH (2019). Outcomes of immunosuppression minimization and withdrawal early after liver transplantation. Am J Transplant, 19(5), 1397-1409. https://doi.org/10.1111/ajt.15205 PMID: 30506630. PMCID: PMC6482056.
Posttransplant biopsy risk for stable long-term pediatric liver transplant recipients: 451 percutaneous biopsies from two multicenter immunosuppression withdrawal trials
Perito ER, Martinez M, Turmelle YP, Mason K, Spain KM, Bucuvalas JC, Feng S
Associated Clinical Trial(s):
Perito ER, Martinez M, Turmelle YP, Mason K, Spain KM, Bucuvalas JC, Feng S (2019). Posttransplant biopsy risk for stable long-term pediatric liver transplant recipients: 451 percutaneous biopsies from two multicenter immunosuppression withdrawal trials. Am J Transplant, 19(5), 1545-1551. https://doi.org/10.1111/ajt.15255 PMID: 30614623. PMCID: PMC6482080.
The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis
Berti A, Warner R, Johnson K, Cornec D, Schroeder DR, Kabat BF, Langford CA, Kallenberg CGM, Seo P, Spiera RF, St Clair EW, Fervenza FC, Stone JH, Monach PA, Specks U, Merkel PA, RAVE-ITN Research Group
Associated Clinical Trial(s):
Berti A, Warner R, Johnson K, Cornec D, Schroeder DR, Kabat BF, Langford CA, Kallenberg CGM, Seo P, Spiera RF, St Clair EW, Fervenza FC, Stone JH, Monach PA, Specks U, Merkel PA, RAVE-ITN Research Group (2019). The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis. J Autoimmun, 105, 102302. https://doi.org/10.1016/j.jaut.2019.07.001 PMID: 31320177. PMCID: PMC7217333.
Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Kronbichler A, Leierer J, Shin JI, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CGM, St Clair EW, Brunetta P, Fervenza FC, Geetha D, Keogh KA, Monach PA, Ytterberg SR, Mayer G, Specks U, Stone JH, RAVE−ITN Research Group
Associated Clinical Trial(s):
Kronbichler A, Leierer J, Shin JI, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CGM, St Clair EW, Brunetta P, Fervenza FC, Geetha D, Keogh KA, Monach PA, Ytterberg SR, Mayer G, Specks U, Stone JH, RAVE−ITN Research Group (2019). Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol, 71(11), 1888-1893. https://doi.org/10.1002/art.41017 PMID: 31216123. PMCID: PMC6899947.
Disease Activity, Antineutrophil Cytoplasmic Antibody Type, and Lipid Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Wallace ZS, Fu X, Liao K, Kallenberg CGM, Langford CA, Merkel PA, Monach P, Seo P, Specks U, Spiera R, St Clair EW, Zhang Y, Choi H, Stone JH
Associated Clinical Trial(s):
Wallace ZS, Fu X, Liao K, Kallenberg CGM, Langford CA, Merkel PA, Monach P, Seo P, Specks U, Spiera R, St Clair EW, Zhang Y, Choi H, Stone JH (2019). Disease Activity, Antineutrophil Cytoplasmic Antibody Type, and Lipid Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol, 71(11), 1879-1887. https://doi.org/10.1002/art.41006 PMID: 31162829. PMCID: PMC6944270.
Self-tolerance curtails the B cell repertoire to microbial epitopes
Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G
Associated Clinical Trial(s):
Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G (2019). Self-tolerance curtails the B cell repertoire to microbial epitopes. JCI Insight, 4(10). https://doi.org/10.1172/jci.insight.122551 PMID: 31092727. PMCID: PMC6542615.
Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance
Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E
Associated Clinical Trial(s):
Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E (2019). Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. J Immunol, 202(5), 1373-1382. https://doi.org/10.4049/jimmunol.1801425 PMID: 30683697. PMCID: PMC6481683.
Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity
Tsilochristou O, du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, Bahnson HT, Radulovic S, Basting M, Plaut M, Lack G, Immune Tolerance Network Learning Early About Peanut Allergy Study Team
Associated Clinical Trial(s):
Tsilochristou O, du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, Bahnson HT, Radulovic S, Basting M, Plaut M, Lack G, Immune Tolerance Network Learning Early About Peanut Allergy Study Team (2019). Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity. J Allergy Clin Immunol, 144(2), 494-503. https://doi.org/10.1016/j.jaci.2019.04.025 PMID: 31160034.
The MALT1 locus and peanut avoidance in the risk for peanut allergy
Winters A, Bahnson HT, Ruczinski I, Boorgula MP, Malley C, Keramati AR, Chavan S, Larson D, Cerosaletti K, Sayre PH, Plaut M, Du Toit G, Lack G, Barnes KC, Nepom GT, Mathias RA, Immune Tolerance Network LEAP Study Team
Associated Clinical Trial(s):
Winters A, Bahnson HT, Ruczinski I, Boorgula MP, Malley C, Keramati AR, Chavan S, Larson D, Cerosaletti K, Sayre PH, Plaut M, Du Toit G, Lack G, Barnes KC, Nepom GT, Mathias RA, Immune Tolerance Network LEAP Study Team (2019). The MALT1 locus and peanut avoidance in the risk for peanut allergy. J Allergy Clin Immunol, 143(6), 2326-2329. https://doi.org/10.1016/j.jaci.2019.02.016 PMID: 30825465. PMCID: PMC6556406.
The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis
Rhee RL, Davis JC, Ding L, Fervenza FC, Hoffman GS, Kallenberg CGM, Langford CA, McCune WJ, Monach PA, Seo P, Spiera R, St Clair EW, Specks U, Stone JH, Merkel PA
Associated Clinical Trial(s):
Rhee RL, Davis JC, Ding L, Fervenza FC, Hoffman GS, Kallenberg CGM, Langford CA, McCune WJ, Monach PA, Seo P, Spiera R, St Clair EW, Specks U, Stone JH, Merkel PA (2018). The Utility of Urinalysis in Determining the Risk of Renal Relapse in ANCA-Associated Vasculitis. Clin J Am Soc Nephrol, 13(2), 251-257. https://doi.org/10.2215/CJN.04160417 PMID: 29371340. PMCID: PMC5967421.
Reply to Christakoudi and Hernandez-Fuentes: We agree-Let's move on
Asare A, Kanaparthi S, Lim N, Newell KA, Turka LA
Associated Clinical Trial(s):
Asare A, Kanaparthi S, Lim N, Newell KA, Turka LA (2018). Reply to Christakoudi and Hernandez-Fuentes: We agree-Let's move on. Am J Transplant, 18(1), 273. https://doi.org/10.1111/ajt.14569 PMID: 29087040.
FRI0305 Phase 2 trial of induction therapy with anti-cd20 (RITUXIMAB) followed by maintenance therapy with anti-baff (BELIMUMAB) in patients with active lupus nephritis
Aranow C, Dall'Era M, Byron M, Ding L, Smilek D, Diamond B, Wofsy D
Associated Clinical Trial(s):
Aranow C, Dall'Era M, Byron M, Ding L, Smilek D, Diamond B, Wofsy D (2018). FRI0305 Phase 2 trial of induction therapy with anti-cd20 (RITUXIMAB) followed by maintenance therapy with anti-baff (BELIMUMAB) in patients with active lupus nephritis. Ann Rheum Dis, 690. https://dx.doi.org/10.1136/annrheumdis-2018-eular.5711
Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics
Weir GC, Ehlers MR, Harris KM, Kanaparthi S, Long A, Phippard D, Weiner LJ, Jepson B, McNamara JG, Koulmanda M, Strom TB, ITN RETAIN Study Team
Associated Clinical Trial(s):
Weir GC, Ehlers MR, Harris KM, Kanaparthi S, Long A, Phippard D, Weiner LJ, Jepson B, McNamara JG, Koulmanda M, Strom TB, ITN RETAIN Study Team (2018). Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: An open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics. Pediatr Diabetes, 19(5), 945-954. https://doi.org/10.1111/pedi.12660 PMID: 29473705. PMCID: PMC6030471.
Immune monitoring of transplant patients in transient mixed chimerism tolerance trials
Sykes M
Associated Clinical Trial(s):
Sykes M (2018). Immune monitoring of transplant patients in transient mixed chimerism tolerance trials. Hum Immunol, 79(5), 334-342. https://doi.org/10.1016/j.humimm.2017.12.011 PMID: 29289741. PMCID: PMC5924718.
Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients
Newell KA, Adams AB, Turka LA
Associated Clinical Trial(s):
Newell KA, Adams AB, Turka LA (2018). Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients. Hum Immunol, 79(5), 380-387. https://doi.org/10.1016/j.humimm.2018.02.007 PMID: 29448053. PMCID: PMC5924709.
Early expansion of donor-specific Tregs in tolerant kidney transplant recipients
Savage TM, Shonts BA, Obradovic A, Dewolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho SH, Tang Q, Turka LA, Shen Y, Sykes M
Associated Clinical Trial(s):
Savage TM, Shonts BA, Obradovic A, Dewolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho SH, Tang Q, Turka LA, Shen Y, Sykes M (2018). Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. JCI Insight, 3(22). https://doi.org/10.1172/jci.insight.124086 PMID: 30429370. PMCID: PMC6302945.
Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants
Feng S, Bucuvalas JC, Demetris AJ, Burrell BE, Spain KM, Kanaparthi S, Magee JC, Ikle D, Lesniak A, Lozano JJ, Alonso EM, Bray RA, Bridges NE, Doo E, Gebel HM, Gupta NA, Himes RW, Jackson AM, Lobritto SJ, Mazariegos GV, Ng VL, Rand EB, Sherker AH, Sundaram S, Turmelle YP, Sanchez-Fueyo A
Associated Clinical Trial(s):
Feng S, Bucuvalas JC, Demetris AJ, Burrell BE, Spain KM, Kanaparthi S, Magee JC, Ikle D, Lesniak A, Lozano JJ, Alonso EM, Bray RA, Bridges NE, Doo E, Gebel HM, Gupta NA, Himes RW, Jackson AM, Lobritto SJ, Mazariegos GV, Ng VL, Rand EB, Sherker AH, Sundaram S, Turmelle YP, Sanchez-Fueyo A (2018). Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants. Gastroenterology, 155(6), 1838-1851.e7. https://doi.org/10.1053/j.gastro.2018.08.023 PMID: 30144432. PMCID: PMC6279538.
Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity
Harris KM, Lu T, Lim N, Turka LA
Associated Clinical Trial(s):
Harris KM, Lu T, Lim N, Turka LA (2018). Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity. Front Immunol, 9, 100. https://doi.org/10.3389/fimmu.2018.00100 PMID: 29456529. PMCID: PMC5801415.
Basophil Activation Test: Old and New Applications in Allergy
Hemmings O, Kwok M, McKendry R, Santos AF
Associated Clinical Trial(s):
Hemmings O, Kwok M, McKendry R, Santos AF (2018). Basophil Activation Test: Old and New Applications in Allergy. Curr Allergy Asthma Rep, 18(12), 77. https://doi.org/10.1007/s11882-018-0831-5 PMID: 30430289. PMCID: PMC6244909.
The challenges of preventing food allergy: Lessons learned from LEAP and EAT
Fisher HR, Du Toit G, Bahnson HT, Lack G
Associated Clinical Trial(s):
Fisher HR, Du Toit G, Bahnson HT, Lack G (2018). The challenges of preventing food allergy: Lessons learned from LEAP and EAT. Ann Allergy Asthma Immunol, 121(3), 313-319. https://doi.org/10.1016/j.anai.2018.06.008 PMID: 29909054.
Mechanisms of food allergy
Sampson HA, O'Mahony L, Burks AW, Plaut M, Lack G, Akdis CA
Associated Clinical Trial(s):
Sampson HA, O'Mahony L, Burks AW, Plaut M, Lack G, Akdis CA (2018). Mechanisms of food allergy. J Allergy Clin Immunol, 141(1), 11-19. https://doi.org/10.1016/j.jaci.2017.11.005 PMID: 29307410.
Treatment for food allergy
Burks AW, Sampson HA, Plaut M, Lack G, Akdis CA
Associated Clinical Trial(s):
Burks AW, Sampson HA, Plaut M, Lack G, Akdis CA (2018). Treatment for food allergy. J Allergy Clin Immunol, 141(1), 1-9. https://doi.org/10.1016/j.jaci.2017.11.004 PMID: 29307409.
Food allergy
Renz H, Allen KJ, Sicherer SH, Sampson HA, Lack G, Beyer K, Oettgen HC
Associated Clinical Trial(s):
Renz H, Allen KJ, Sicherer SH, Sampson HA, Lack G, Beyer K, Oettgen HC (2018). Food allergy. Nat Rev Dis Primers, 4, 17098. https://doi.org/10.1038/nrdp.2017.98 PMID: 29300005.
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management
Sicherer SH, Sampson HA
Associated Clinical Trial(s):
Sicherer SH, Sampson HA (2018). Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol, 141(1), 41-58. https://doi.org/10.1016/j.jaci.2017.11.003 PMID: 29157945.
