Prevention of type 1A diabetes mellitus
Eisenbarth GS
Associated Clinical Trial(s):
Eisenbarth GS (2012). Prevention of type 1A diabetes mellitus. Endocr Pract, 18(5), 745-9. https://doi.org/10.4158/EP12080.OR PMID: 22548954. PMCID: PMC4976770.
Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes
Pietropaolo M, Towns R, Eisenbarth GS
Associated Clinical Trial(s):
Pietropaolo M, Towns R, Eisenbarth GS (2012). Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes. Cold Spring Harb Perspect Med, 2(10). https://doi.org/10.1101/cshperspect.a012831 PMID: 23028135. PMCID: PMC3475400.
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ, Diabetes TrialNet and the Immune Tolerance Network
Associated Clinical Trial(s):
Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ, Diabetes TrialNet and the Immune Tolerance Network (2012). Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes, 61(9), 2340-8. https://doi.org/10.2337/db12-0049 PMID: 22721971. PMCID: PMC3425404.
Digital transplantation pathology: combining whole slide imaging, multiplex staining and automated image analysis
Isse K, Lesniak A, Grama K, Roysam B, Minervini MI, Demetris AJ
Associated Clinical Trial(s):
Isse K, Lesniak A, Grama K, Roysam B, Minervini MI, Demetris AJ (2012). Digital transplantation pathology: combining whole slide imaging, multiplex staining and automated image analysis. Am J Transplant, 12(1), 27-37. https://doi.org/10.1111/j.1600-6143.2011.03797.x PMID: 22053785. PMCID: PMC3627485.
Lymphodepletion and homeostatic proliferation: implications for transplantation
Tchao NK, Turka LA
Associated Clinical Trial(s):
Tchao NK, Turka LA (2012). Lymphodepletion and homeostatic proliferation: implications for transplantation. Am J Transplant, 12(5), 1079-90. https://doi.org/10.1111/j.1600-6143.2012.04008.x PMID: 22420320.
Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients
Haynes LD, Jankowska-Gan E, Sheka A, Keller MR, Hernandez-Fuentes MP, Lechler RI, Seyfert-Margolis V, Turka LA, Newell KA, Burlingham WJ
Associated Clinical Trial(s):
Haynes LD, Jankowska-Gan E, Sheka A, Keller MR, Hernandez-Fuentes MP, Lechler RI, Seyfert-Margolis V, Turka LA, Newell KA, Burlingham WJ (2012). Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients. Am J Transplant, 12(3), 640-8. https://doi.org/10.1111/j.1600-6143.2011.03869.x PMID: 22151236. PMCID: PMC3374729.
Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants
Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA, Tchao NK
Associated Clinical Trial(s):
Feng S, Ekong UD, Lobritto SJ, Demetris AJ, Roberts JP, Rosenthal P, Alonso EM, Philogene MC, Ikle D, Poole KM, Bridges ND, Turka LA, Tchao NK (2012). Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA, 307(3), 283-93. https://doi.org/10.1001/jama.2011.2014 PMID: 22253395.
Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study
Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, Bar-Or A, Vollmer T, Racke M, Stüve O, Schwid S, Goodman A, Kachuck N, Preiningerova J, Weinstock-Guttman B, Calabresi PA, Miller A, Mokhtarani M, Iklé D, Murphy S, Kopetskie H, Ding L, Rosenberg E, Spencer C, Zamvil SS, ITN STAyCIS Study Group, ITN020AI Study Management Team
Associated Clinical Trial(s):
Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, Bar-Or A, Vollmer T, Racke M, Stüve O, Schwid S, Goodman A, Kachuck N, Preiningerova J, Weinstock-Guttman B, Calabresi PA, Miller A, Mokhtarani M, Iklé D, Murphy S, Kopetskie H, Ding L, Rosenberg E, Spencer C, Zamvil SS, ITN STAyCIS Study Group, ITN020AI Study Management Team (2012). Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study. Neurology, 78(15), 1171-8. https://doi.org/10.1212/WNL.0b013e31824f7fdd PMID: 22459680. PMCID: PMC3320055.
Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis
Monach PA, Kümpers P, Lukasz A, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Carette S, Ding L, Hoffman GS, Iklé D, Kallenberg CG, Khalidi NA, Langford CA, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Haubitz M, Merkel PA
Associated Clinical Trial(s):
Monach PA, Kümpers P, Lukasz A, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Carette S, Ding L, Hoffman GS, Iklé D, Kallenberg CG, Khalidi NA, Langford CA, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Haubitz M, Merkel PA (2012). Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis. PLoS One, 7(1), e30197. https://doi.org/10.1371/journal.pone.0030197 PMID: 22279570. PMCID: PMC3261176.
Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy
Shamji MH, Ljørring C, Francis JN, Calderon MA, Larché M, Kimber I, Frew AJ, Ipsen H, Lund K, Würtzen PA, Durham SR
Associated Clinical Trial(s):
Shamji MH, Ljørring C, Francis JN, Calderon MA, Larché M, Kimber I, Frew AJ, Ipsen H, Lund K, Würtzen PA, Durham SR (2012). Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy. Allergy, 67(2), 217-26. https://doi.org/10.1111/j.1398-9995.2011.02745.x PMID: 22077562.
Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes
Scadding GW, Calderon MA, Bellido V, Koed GK, Nielsen NC, Lund K, Togias A, Phippard D, Turka LA, Hansel TT, Durham SR, Wurtzen PA
Associated Clinical Trial(s):
Scadding GW, Calderon MA, Bellido V, Koed GK, Nielsen NC, Lund K, Togias A, Phippard D, Turka LA, Hansel TT, Durham SR, Wurtzen PA (2012). Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. J Immunol Methods, 384(1-2), 25-32. https://doi.org/10.1016/j.jim.2012.06.013 PMID: 22759401.
Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes
Herold KC, Pescovitz MD, McGee P, Krause-Steinrauf H, Spain LM, Bourcier K, Asare A, Liu Z, Lachin JM, Dosch HM, Type 1 Diabetes TrialNet Anti-CD20 Study Group
Associated Clinical Trial(s):
Herold KC, Pescovitz MD, McGee P, Krause-Steinrauf H, Spain LM, Bourcier K, Asare A, Liu Z, Lachin JM, Dosch HM, Type 1 Diabetes TrialNet Anti-CD20 Study Group (2011). Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes. J Immunol, 187(4), 1998-2005. https://doi.org/10.4049/jimmunol.1100539 PMID: 21775681. PMCID: PMC3150302.
Challenges in the pursuit of immune tolerance
Nepom GT, St Clair EW, Turka LA
Associated Clinical Trial(s):
Nepom GT, St Clair EW, Turka LA (2011). Challenges in the pursuit of immune tolerance. Immunol Rev, 241(1), 49-62. https://doi.org/10.1111/j.1600-065X.2011.01003.x PMID: 21488889. PMCID: PMC3092524.
Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction
Strober S, Spitzer TR, Lowsky R, Sykes M
Associated Clinical Trial(s):
Strober S, Spitzer TR, Lowsky R, Sykes M (2011). Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction. Semin Immunol, 23(4), 273-81. https://doi.org/10.1016/j.smim.2011.05.001 PMID: 21705229. PMCID: PMC3201788.
Preclinical and clinical studies on the induction of renal allograft tolerance through transient mixed chimerism
Kawai T, Cosimi AB, Sachs DH
Associated Clinical Trial(s):
Kawai T, Cosimi AB, Sachs DH (2011). Preclinical and clinical studies on the induction of renal allograft tolerance through transient mixed chimerism. Curr Opin Organ Transplant, 16(4), 366-71. https://doi.org/10.1097/MOT.0b013e3283484b2c PMID: 21666482. PMCID: PMC3151013.
Regulatory cells and cell signatures in clinical transplantation tolerance
Newell KA, Phippard D, Turka LA
Associated Clinical Trial(s):
Newell KA, Phippard D, Turka LA (2011). Regulatory cells and cell signatures in clinical transplantation tolerance. Curr Opin Immunol, 23(5), 655-9. https://doi.org/10.1016/j.coi.2011.07.008 PMID: 21982510.
Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease
Spitzer TR, Sykes M, Tolkoff-Rubin N, Kawai T, McAfee SL, Dey BR, Ballen K, Delmonico F, Saidman S, Sachs DH, Cosimi AB
Associated Clinical Trial(s):
Spitzer TR, Sykes M, Tolkoff-Rubin N, Kawai T, McAfee SL, Dey BR, Ballen K, Delmonico F, Saidman S, Sachs DH, Cosimi AB (2011). Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation, 91(6), 672-6. https://doi.org/10.1097/TP.0b013e31820a3068 PMID: 21217460. PMCID: PMC3232059.
Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation
Andreola G, Chittenden M, Shaffer J, Cosimi AB, Kawai T, Cotter P, Locascio SA, Morokata T, Dey BR, Tolkoff-Rubin NT, Preffer F, Bonnefoix T, Kattleman K, Spitzer TR, Sachs DH, Sykes M
Associated Clinical Trial(s):
Andreola G, Chittenden M, Shaffer J, Cosimi AB, Kawai T, Cotter P, Locascio SA, Morokata T, Dey BR, Tolkoff-Rubin NT, Preffer F, Bonnefoix T, Kattleman K, Spitzer TR, Sachs DH, Sykes M (2011). Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation. Am J Transplant, 11(6), 1236-47. https://doi.org/10.1111/j.1600-6143.2011.03566.x PMID: 21645255. PMCID: PMC3140222.
Immuno-intervention for the induction of transplantation tolerance through mixed chimerism
Sachs DH, Sykes M, Kawai T, Cosimi AB
Associated Clinical Trial(s):
Sachs DH, Sykes M, Kawai T, Cosimi AB (2011). Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol, 23(3), 165-73. https://doi.org/10.1016/j.smim.2011.07.001 PMID: 21839648. PMCID: PMC3178004.
Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allografts
Farris AB, Taheri D, Kawai T, Fazlollahi L, Wong W, Tolkoff-Rubin N, Spitzer TR, Iafrate AJ, Preffer FI, Locascio SA, Sprangers B, Saidman S, Smith RN, Cosimi AB, Sykes M, Sachs DH, Colvin RB
Associated Clinical Trial(s):
ITN036ST
Mixed Chimerism
,
Farris AB, Taheri D, Kawai T, Fazlollahi L, Wong W, Tolkoff-Rubin N, Spitzer TR, Iafrate AJ, Preffer FI, Locascio SA, Sprangers B, Saidman S, Smith RN, Cosimi AB, Sykes M, Sachs DH, Colvin RB (2011). Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allografts. Am J Transplant, 11(7), 1464-77. https://doi.org/10.1111/j.1600-6143.2011.03572.x PMID: 21668634. PMCID: PMC3128680.
Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis
Monach PA, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Ding L, Fervenza FC, Fessler BJ, Hoffman GS, Ikle D, Kallenberg CG, Langford CA, Mueller M, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Gu YZ, Snyder RD, Merkel PA
Associated Clinical Trial(s):
Monach PA, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Ding L, Fervenza FC, Fessler BJ, Hoffman GS, Ikle D, Kallenberg CG, Langford CA, Mueller M, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Gu YZ, Snyder RD, Merkel PA (2011). Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum, 63(12), 3988-97. https://doi.org/10.1002/art.30615 PMID: 21953143. PMCID: PMC3227746.
Design of the Rituximab in ANCA-associated Vasculitis (RAVE) Trial
Specks U, Merkel PA, Hoffman GS, Langford CA, Spiera R, Seo P, Kallenberg CGM, St. Clair EW, Ding L, Webber L, Mokhtarani M, Tchao NK, Sayre PH, Seyfert-Margolis V, Ikle D, Brunetta P, Zhang D, Sejismundo L, Mueller M, Stone JH
Associated Clinical Trial(s):
Specks U, Merkel PA, Hoffman GS, Langford CA, Spiera R, Seo P, Kallenberg CGM, St. Clair EW, Ding L, Webber L, Mokhtarani M, Tchao NK, Sayre PH, Seyfert-Margolis V, Ikle D, Brunetta P, Zhang D, Sejismundo L, Mueller M, Stone JH (2011). Design of the Rituximab in ANCA-associated Vasculitis (RAVE) Trial. The Open Arthritis Journal, 4 (1), 1-18. https://doi.org/10.2174/1876539401104010001
Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis
Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA
Associated Clinical Trial(s):
Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA (2011). Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol, 187(2), 1039-46. https://doi.org/10.4049/jimmunol.1001543 PMID: 21653833. PMCID: PMC3131477.
Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies
James LK, Shamji MH, Walker SM, Wilson DR, Wachholz PA, Francis JN, Jacobson MR, Kimber I, Till SJ, Durham SR
Associated Clinical Trial(s):
James LK, Shamji MH, Walker SM, Wilson DR, Wachholz PA, Francis JN, Jacobson MR, Kimber I, Till SJ, Durham SR (2011). Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. J Allergy Clin Immunol, 127(2), 509-516.e1-5. https://doi.org/10.1016/j.jaci.2010.12.1080 PMID: 21281875.
Ten years of the Immune Tolerance Network: an integrated clinical research organization
Bluestone JA, Krensky AM, Turka LA, Rotrosen D, Matthews JB
Associated Clinical Trial(s):
Bluestone JA, Krensky AM, Turka LA, Rotrosen D, Matthews JB (2010). Ten years of the Immune Tolerance Network: an integrated clinical research organization. Sci Transl Med, 2(19), 19cm7. https://doi.org/10.1126/scitranslmed.3000672 PMID: 20371484.
Classification of high-dimensional data with ensemble of logistic regression models
Lim N, Ahn H, Moon H, Chen JJ
Associated Clinical Trial(s):
Lim N, Ahn H, Moon H, Chen JJ (2010). Classification of high-dimensional data with ensemble of logistic regression models. J Biopharm Stat, 20(1), 160-71. https://doi.org/10.1080/10543400903280639 PMID: 20077255.
The Immune Tolerance Network at 10 years: tolerance research at the bedside
Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA
Associated Clinical Trial(s):
Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA (2010). The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol, 10(11), 797-803. https://doi.org/10.1038/nri2869 PMID: 20972473.
Adding value to liver (and allograft) biopsy evaluation using a combination of multiplex quantum dot immunostaining, high-resolution whole-slide digital imaging, and automated image analysis
Isse K, Grama K, Abbott IM, Lesniak A, Lunz JG, Lee WM, Specht S, Corbitt N, Mizuguchi Y, Roysam B, Demetris AJ
Associated Clinical Trial(s):
Isse K, Grama K, Abbott IM, Lesniak A, Lunz JG, Lee WM, Specht S, Corbitt N, Mizuguchi Y, Roysam B, Demetris AJ (2010). Adding value to liver (and allograft) biopsy evaluation using a combination of multiplex quantum dot immunostaining, high-resolution whole-slide digital imaging, and automated image analysis. Clin Liver Dis, 14(4), 669-85. https://doi.org/10.1016/j.cld.2010.07.004 PMID: 21055689.
Per-channel basis normalization methods for flow cytometry data
Hahne F, Khodabakhshi AH, Bashashati A, Wong CJ, Gascoyne RD, Weng AP, Seyfert-Margolis V, Bourcier K, Asare A, Lumley T, Gentleman R, Brinkman RR
Associated Clinical Trial(s):
Hahne F, Khodabakhshi AH, Bashashati A, Wong CJ, Gascoyne RD, Weng AP, Seyfert-Margolis V, Bourcier K, Asare A, Lumley T, Gentleman R, Brinkman RR (2010). Per-channel basis normalization methods for flow cytometry data. Cytometry A, 77(2), 121-31. https://doi.org/10.1002/cyto.a.20823 PMID: 19899135. PMCID: PMC3648208.
Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
Matthews JB, Staeva TP, Bernstein PL, Peakman M, von Herrath M, ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
Associated Clinical Trial(s):
Matthews JB, Staeva TP, Bernstein PL, Peakman M, von Herrath M, ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group (2010). Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group. Clin Exp Immunol, 160(2), 176-84. https://doi.org/10.1111/j.1365-2249.2010.04153.x PMID: 20629979. PMCID: PMC2857940.
