Tolerance: one transplant for life
Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ
Associated Clinical Trial(s):
Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ (2014). Tolerance: one transplant for life. Transplantation, 98(2), 117-21. https://doi.org/10.1097/TP.0000000000000260 PMID: 24926829. PMCID: PMC4101034.
Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression
Kawai T, Sachs DH, Sprangers B, Spitzer TR, Saidman SL, Zorn E, Tolkoff-Rubin N, Preffer F, Crisalli K, Gao B, Wong W, Morris H, LoCascio SA, Sayre P, Shonts B, Williams WW Jr, Smith RN, Colvin RB, Sykes M, Cosimi AB
Associated Clinical Trial(s):
ITN036ST
Mixed Chimerism
,
Kawai T, Sachs DH, Sprangers B, Spitzer TR, Saidman SL, Zorn E, Tolkoff-Rubin N, Preffer F, Crisalli K, Gao B, Wong W, Morris H, LoCascio SA, Sayre P, Shonts B, Williams WW Jr, Smith RN, Colvin RB, Sykes M, Cosimi AB (2014). Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant, 14(7), 1599-611. https://doi.org/10.1111/ajt.12731 PMID: 24903438. PMCID: PMC4228952.
Restoring the balance: immunotherapeutic combinations for autoimmune disease
Smilek DE, Ehlers MR, Nepom GT
Associated Clinical Trial(s):
Smilek DE, Ehlers MR, Nepom GT (2014). Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech, 7(5), 503-13. https://doi.org/10.1242/dmm.015099 PMID: 24795433. PMCID: PMC4007402.
Immune-modulating effects of alpha-1 antitrypsin
Ehlers MR
Associated Clinical Trial(s):
Ehlers MR (2014). Immune-modulating effects of alpha-1 antitrypsin. Biol Chem, 395(10), 1187-93. https://doi.org/10.1515/hsz-2014-0161 PMID: 24854541. PMCID: PMC4237306.
Treatment of lupus nephritis with abatacept: the Abatacept and Cyclophosphamide Combination Efficacy and Safety Study
ACCESS Trial Group
Associated Clinical Trial(s):
ACCESS Trial Group (2014). Treatment of lupus nephritis with abatacept: the Abatacept and Cyclophosphamide Combination Efficacy and Safety Study. Arthritis Rheumatol, 66(11), 3096-104. https://doi.org/10.1002/art.38790 PMID: 25403681. PMCID: PMC4528976.
Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis
Miloslavsky EM, Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Viviano L, Ding L, Iklé D, Villarreal M, Jepson B, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Stone JH, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group
Associated Clinical Trial(s):
Miloslavsky EM, Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Viviano L, Ding L, Iklé D, Villarreal M, Jepson B, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Stone JH, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group (2014). Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol, 66(11), 3151-9. https://doi.org/10.1002/art.38788 PMID: 25047592. PMCID: PMC4229846.
T cell repertoire following autologous stem cell transplantation for multiple sclerosis
Muraro PA, Robins H, Malhotra S, Howell M, Phippard D, Desmarais C, de Paula Alves Sousa A, Griffith LM, Lim N, Nash RA, Turka LA
Associated Clinical Trial(s):
Muraro PA, Robins H, Malhotra S, Howell M, Phippard D, Desmarais C, de Paula Alves Sousa A, Griffith LM, Lim N, Nash RA, Turka LA (2014). T cell repertoire following autologous stem cell transplantation for multiple sclerosis. J Clin Invest, 124(3), 1168-72. https://doi.org/10.1172/JCI71691 PMID: 24531550. PMCID: PMC3934160.
Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy
Vickery BP, Scurlock AM, Kulis M, Steele PH, Kamilaris J, Berglund JP, Burk C, Hiegel A, Carlisle S, Christie L, Perry TT, Pesek RD, Sheikh S, Virkud Y, Smith PB, Shamji MH, Durham SR, Jones SM, Burks AW
Associated Clinical Trial(s):
Vickery BP, Scurlock AM, Kulis M, Steele PH, Kamilaris J, Berglund JP, Burk C, Hiegel A, Carlisle S, Christie L, Perry TT, Pesek RD, Sheikh S, Virkud Y, Smith PB, Shamji MH, Durham SR, Jones SM, Burks AW (2014). Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol, 133(2), 468-75. https://doi.org/10.1016/j.jaci.2013.11.007 PMID: 24361082. PMCID: PMC3960331.
Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis
Monach PA, Warner RL, Tomasson G, Specks U, Stone JH, Ding L, Fervenza FC, Fessler BJ, Hoffman GS, Iklé D, Kallenberg CG, Krischer J, Langford CA, Mueller M, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Johnson KJ, Merkel PA
Associated Clinical Trial(s):
Monach PA, Warner RL, Tomasson G, Specks U, Stone JH, Ding L, Fervenza FC, Fessler BJ, Hoffman GS, Iklé D, Kallenberg CG, Krischer J, Langford CA, Mueller M, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Johnson KJ, Merkel PA (2013). Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis. Ann Rheum Dis, 72(8), 1342-50. https://doi.org/10.1136/annrheumdis-2012-201981 PMID: 22975753. PMCID: PMC4982463.
Ancillary study management systems: a review of needs
Nelson EK, Piehler B, Rauch A, Ramsay S, Holman D, Asare S, Asare A, Igra M
Associated Clinical Trial(s):
Nelson EK, Piehler B, Rauch A, Ramsay S, Holman D, Asare S, Asare A, Igra M (2013). Ancillary study management systems: a review of needs. BMC Med Inform Decis Mak, 13, 5. https://doi.org/10.1186/1472-6947-13-5 PMID: 23294514. PMCID: PMC3564696.
Type 1 diabetes: primary antigen/peptide/register/trimolecular complex
Sosinowski T, Eisenbarth GS
Associated Clinical Trial(s):
Sosinowski T, Eisenbarth GS (2013). Type 1 diabetes: primary antigen/peptide/register/trimolecular complex. Immunol Res, 55(1-3), 270-6. https://doi.org/10.1007/s12026-012-8367-6 PMID: 22956469. PMCID: PMC3936464.
Anti-cytokine therapies in T1D: Concepts and strategies
Nepom GT, Ehlers M, Mandrup-Poulsen T
Associated Clinical Trial(s):
Nepom GT, Ehlers M, Mandrup-Poulsen T (2013). Anti-cytokine therapies in T1D: Concepts and strategies. Clin Immunol, 149(3), 279-85. https://doi.org/10.1016/j.clim.2013.02.003 PMID: 23510726. PMCID: PMC3700624.
Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
Yu L, Dong F, Miao D, Fouts AR, Wenzlau JM, Steck AK
Associated Clinical Trial(s):
Yu L, Dong F, Miao D, Fouts AR, Wenzlau JM, Steck AK (2013). Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity. Diabetes Care, 36(8), 2266-70. https://doi.org/10.2337/dc12-2245 PMID: 23423694. PMCID: PMC3714529.
Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial
Rigby MR, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR, T1DAL Study Team
Associated Clinical Trial(s):
Rigby MR, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR, T1DAL Study Team (2013). Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol, 1(4), 284-94. https://doi.org/10.1016/S2213-8587(13)70111-6 PMID: 24622414. PMCID: PMC3957186.
Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
Gitelman SE, Gottlieb PA, Rigby MR, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, Ding L, Bluestone JA, Ehlers MR, START Study Team
Associated Clinical Trial(s):
Gitelman SE, Gottlieb PA, Rigby MR, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, Ding L, Bluestone JA, Ehlers MR, START Study Team (2013). Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol, 1(4), 306-16. https://doi.org/10.1016/S2213-8587(13)70065-2 PMID: 24622416. PMCID: PMC6489466.
Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders
Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA, AbATE Study Team
Associated Clinical Trial(s):
Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA, AbATE Study Team (2013). Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes, 62(11), 3766-74. https://doi.org/10.2337/db13-0345 PMID: 23835333. PMCID: PMC3806618.
Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice
Sarikonda G, Sachithanantham S, Manenkova Y, Kupfer T, Posgai A, Wasserfall C, Bernstein P, Straub L, Pagni PP, Schneider D, Calvo TR, Coulombe M, Herold K, Gill RG, Atkinson M, Nepom G, Ehlers M, Staeva T, Garren H, Steinman L, Chan AC, von Herrath M
Associated Clinical Trial(s):
Sarikonda G, Sachithanantham S, Manenkova Y, Kupfer T, Posgai A, Wasserfall C, Bernstein P, Straub L, Pagni PP, Schneider D, Calvo TR, Coulombe M, Herold K, Gill RG, Atkinson M, Nepom G, Ehlers M, Staeva T, Garren H, Steinman L, Chan AC, von Herrath M (2013). Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice. PLoS One, 8(2), e54712. https://doi.org/10.1371/journal.pone.0054712 PMID: 23405091. PMCID: PMC3566105.
HLA-mismatched renal transplantation without maintenance immunosuppression
Kawai T, Sachs DH, Sykes M, Cosimi AB, Immune Tolerance Network
Associated Clinical Trial(s):
Kawai T, Sachs DH, Sykes M, Cosimi AB, Immune Tolerance Network (2013). HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med, 368(19), 1850-2. https://doi.org/10.1056/NEJMc1213779 PMID: 23656665. PMCID: PMC3760499.
Regulatory T-cell therapy in transplantation: moving to the clinic
Tang Q, Bluestone JA
Associated Clinical Trial(s):
Tang Q, Bluestone JA (2013). Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harb Perspect Med, 3(11). https://doi.org/10.1101/cshperspect.a015552 PMID: 24186492. PMCID: PMC3808774.
Tissue biopsy monitoring of operational tolerance in liver allograft recipients
Demetris AJ, Isse K
Associated Clinical Trial(s):
Demetris AJ, Isse K (2013). Tissue biopsy monitoring of operational tolerance in liver allograft recipients. Curr Opin Organ Transplant, 18(3), 345-53. https://doi.org/10.1097/MOT.0b013e3283615d48 PMID: 23619515.
Tolerance induction: hematopoietic chimerism
Kawai T, Sachs DH
Associated Clinical Trial(s):
Kawai T, Sachs DH (2013). Tolerance induction: hematopoietic chimerism. Curr Opin Organ Transplant, 18(4), 402-7. https://doi.org/10.1097/MOT.0b013e328363621d PMID: 23838644.
Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells
Isse K, Lesniak A, Grama K, Maier J, Specht S, Castillo-Rama M, Lunz J, Roysam B, Michalopoulos G, Demetris AJ
Associated Clinical Trial(s):
Isse K, Lesniak A, Grama K, Maier J, Specht S, Castillo-Rama M, Lunz J, Roysam B, Michalopoulos G, Demetris AJ (2013). Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells. Hepatology, 57(4), 1632-43. https://doi.org/10.1002/hep.26131 PMID: 23150208. PMCID: PMC3612393.
Participant-level data and the new frontier in trial transparency
Zarin DA
Associated Clinical Trial(s):
Zarin DA (2013). Participant-level data and the new frontier in trial transparency. N Engl J Med, 369(5), 468-9. https://doi.org/10.1056/NEJMe1307268 PMID: 23902488.
Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis
Miloslavsky EM, Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Viviano L, Ding L, Sejismundo LP, Mieras K, Iklé D, Jepson B, Mueller M, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Stone JH, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group
Associated Clinical Trial(s):
Miloslavsky EM, Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Viviano L, Ding L, Sejismundo LP, Mieras K, Iklé D, Jepson B, Mueller M, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Stone JH, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group (2013). Clinical outcomes of remission induction therapy for severe antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum, 65(9), 2441-9. https://doi.org/10.1002/art.38044 PMID: 23754238. PMCID: PMC4949954.
Efficacy of remission-induction regimens for ANCA-associated vasculitis
Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Viviano L, Tchao NK, Phippard DJ, Asare AL, Lim N, Ikle D, Jepson B, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Mueller M, Sejismundo LP, Mieras K, Stone JH, RAVE-ITN Research Group
Associated Clinical Trial(s):
Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Viviano L, Tchao NK, Phippard DJ, Asare AL, Lim N, Ikle D, Jepson B, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh K, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR, Mueller M, Sejismundo LP, Mieras K, Stone JH, RAVE-ITN Research Group (2013). Efficacy of remission-induction regimens for ANCA-associated vasculitis. N Engl J Med, 369(5), 417-27. https://doi.org/10.1056/NEJMoa1213277 PMID: 23902481. PMCID: PMC5953195.
Estimating the ratio of CD4+ to CD8+ T cells using high-throughput sequence data
Emerson R, Sherwood A, Desmarais C, Malhotra S, Phippard D, Robins H
Associated Clinical Trial(s):
Emerson R, Sherwood A, Desmarais C, Malhotra S, Phippard D, Robins H (2013). Estimating the ratio of CD4+ to CD8+ T cells using high-throughput sequence data. J Immunol Methods, 391(1-2), 14-21. https://doi.org/10.1016/j.jim.2013.02.002 PMID: 23428915.
Prophylactic use of sublingual allergen immunotherapy in high-risk children: a pilot study
Holt PG, Sly PD, Sampson HA, Robinson P, Loh R, Lowenstein H, Calatroni A, Sayre P
Associated Clinical Trial(s):
Holt PG, Sly PD, Sampson HA, Robinson P, Loh R, Lowenstein H, Calatroni A, Sayre P (2013). Prophylactic use of sublingual allergen immunotherapy in high-risk children: a pilot study. J Allergy Clin Immunol, 132(4), 991-3.e1. https://doi.org/10.1016/j.jaci.2013.04.049 PMID: 23768574.
Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study
Du Toit G, Roberts G, Sayre PH, Plaut M, Bahnson HT, Mitchell H, Radulovic S, Chan S, Fox A, Turcanu V, Lack G, Learning Early About Peanut Allergy (LEAP) Study Team
Associated Clinical Trial(s):
Du Toit G, Roberts G, Sayre PH, Plaut M, Bahnson HT, Mitchell H, Radulovic S, Chan S, Fox A, Turcanu V, Lack G, Learning Early About Peanut Allergy (LEAP) Study Team (2013). Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study. J Allergy Clin Immunol, 131(1), 135-43.e1-12. https://doi.org/10.1016/j.jaci.2012.09.015 PMID: 23174658.
QUAliFiER: an automated pipeline for quality assessment of gated flow cytometry data
Finak G, Jiang W, Pardo J, Asare A, Gottardo R
Associated Clinical Trial(s):
Finak G, Jiang W, Pardo J, Asare A, Gottardo R (2012). QUAliFiER: an automated pipeline for quality assessment of gated flow cytometry data. BMC Bioinformatics, 13, 252. https://doi.org/10.1186/1471-2105-13-252 PMID: 23020243. PMCID: PMC3499158.
Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience
Ehlers MR, Nepom GT
Associated Clinical Trial(s):
Ehlers MR, Nepom GT (2012). Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience. Rev Diabet Stud, 9(4), 359-71. https://doi.org/10.1900/RDS.2012.9.359 PMID: 23804273. PMCID: PMC3740703.
