An interactive web application for the dissemination of human systems immunology data
Speake C, Presnell S, Domico K, Zeitner B, Bjork A, Anderson D, Mason MJ, Whalen E, Vargas O, Popov D, Rinchai D, Jourde-Chiche N, Chiche L, Quinn C, Chaussabel D
Associated Clinical Trial(s):
Speake C, Presnell S, Domico K, Zeitner B, Bjork A, Anderson D, Mason MJ, Whalen E, Vargas O, Popov D, Rinchai D, Jourde-Chiche N, Chiche L, Quinn C, Chaussabel D (2015). An interactive web application for the dissemination of human systems immunology data. J Transl Med, 13, 196. https://doi.org/10.1186/s12967-015-0541-x PMID: 26088622. PMCID: PMC4474328.
Targeting memory T cells in type 1 diabetes
Ehlers MR, Rigby MR
Associated Clinical Trial(s):
Ehlers MR, Rigby MR (2015). Targeting memory T cells in type 1 diabetes. Curr Diab Rep, 15(11), 84. https://doi.org/10.1007/s11892-015-0659-5 PMID: 26370695.
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q
Associated Clinical Trial(s):
Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q (2015). Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med, 7(315), 315ra189. https://doi.org/10.1126/scitranslmed.aad4134 PMID: 26606968. PMCID: PMC4729454.
Evaluation of Candidate Biomarkers of Type 1 Diabetes via the Core for Assay Validation
Speake C, Odegard JM
Associated Clinical Trial(s):
Speake C, Odegard JM (2015). Evaluation of Candidate Biomarkers of Type 1 Diabetes via the Core for Assay Validation. Biomark Insights, 10(Suppl 4), 19-24. https://doi.org/10.4137/BMI.S29697 PMID: 26462120. PMCID: PMC4589091.
Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients
Rigby MR, Harris KM, Pinckney A, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Keyes-Elstein L, Long SA, Kanaparthi S, Lim N, Phippard D, Soppe CL, Fitzgibbon ML, McNamara J, Nepom GT, Ehlers MR
Associated Clinical Trial(s):
Rigby MR, Harris KM, Pinckney A, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Keyes-Elstein L, Long SA, Kanaparthi S, Lim N, Phippard D, Soppe CL, Fitzgibbon ML, McNamara J, Nepom GT, Ehlers MR (2015). Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest, 125(8), 3285-96. https://doi.org/10.1172/JCI81722 PMID: 26193635. PMCID: PMC4623571.
ABO-compatible liver allograft antibody-mediated rejection: an update
Demetris AJ, Zeevi A, O'Leary JG
Associated Clinical Trial(s):
Demetris AJ, Zeevi A, O'Leary JG (2015). ABO-compatible liver allograft antibody-mediated rejection: an update. Curr Opin Organ Transplant, 20(3), 314-24. https://doi.org/10.1097/MOT.0000000000000194 PMID: 25944231. PMCID: PMC4646419.
Tolerance signatures in transplant recipients
Newell KA, Turka LA
Associated Clinical Trial(s):
Newell KA, Turka LA (2015). Tolerance signatures in transplant recipients. Curr Opin Organ Transplant, 20(4), 400-5. https://doi.org/10.1097/MOT.0000000000000207 PMID: 26107969. PMCID: PMC4524570.
Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation
McDonald-Hyman C, Turka LA, Blazar BR
Associated Clinical Trial(s):
McDonald-Hyman C, Turka LA, Blazar BR (2015). Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Sci Transl Med, 7(280), 280rv2. https://doi.org/10.1126/scitranslmed.aaa6853 PMID: 25810312. PMCID: PMC4425354.
Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies
Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ
Associated Clinical Trial(s):
Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ (2015). Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies. Genome Med, 7, 90. https://doi.org/10.1186/s13073-015-0211-x PMID: 26423053. PMCID: PMC4589899.
Posttransplant metabolic syndrome in the withdrawal of immunosuppression in Pediatric Liver Transplant Recipients (WISP-R) pilot trial
Perito ER, Mohammad S, Rosenthal P, Alonso EM, Ekong UD, Lobritto SJ, Feng S
Associated Clinical Trial(s):
Perito ER, Mohammad S, Rosenthal P, Alonso EM, Ekong UD, Lobritto SJ, Feng S (2015). Posttransplant metabolic syndrome in the withdrawal of immunosuppression in Pediatric Liver Transplant Recipients (WISP-R) pilot trial. Am J Transplant, 15(3), 779-85. https://doi.org/10.1111/ajt.13024 PMID: 25648649. PMCID: PMC4426259.
Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients
Newell KA, Asare A, Sanz I, Wei C, Rosenberg A, Gao Z, Kanaparthi S, Asare S, Lim N, Stahly M, Howell M, Knechtle S, Kirk A, Marks WH, Kawai T, Spitzer T, Tolkoff-Rubin N, Sykes M, Sachs DH, Cosimi AB, Burlingham WJ, Phippard D, Turka LA
Associated Clinical Trial(s):
Newell KA, Asare A, Sanz I, Wei C, Rosenberg A, Gao Z, Kanaparthi S, Asare S, Lim N, Stahly M, Howell M, Knechtle S, Kirk A, Marks WH, Kawai T, Spitzer T, Tolkoff-Rubin N, Sykes M, Sachs DH, Cosimi AB, Burlingham WJ, Phippard D, Turka LA (2015). Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients. Am J Transplant, 15(11), 2908-20. https://doi.org/10.1111/ajt.13480 PMID: 26461968. PMCID: PMC4725587.
Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients
Morris H, DeWolf S, Robins H, Sprangers B, LoCascio SA, Shonts BA, Kawai T, Wong W, Yang S, Zuber J, Shen Y, Sykes M
Associated Clinical Trial(s):
ITN036ST
Mixed Chimerism
,
Morris H, DeWolf S, Robins H, Sprangers B, LoCascio SA, Shonts BA, Kawai T, Wong W, Yang S, Zuber J, Shen Y, Sykes M (2015). Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients. Sci Transl Med, 7(272), 272ra10. https://doi.org/10.1126/scitranslmed.3010760 PMID: 25632034. PMCID: PMC4360892.
Crossing the Atlantic: the Euro-Lupus Nephritis regimen in North America
Wofsy D, Diamond B, Houssiau FA
Associated Clinical Trial(s):
Wofsy D, Diamond B, Houssiau FA (2015). Crossing the Atlantic: the Euro-Lupus Nephritis regimen in North America. Arthritis Rheumatol, 67(5), 1144-6. https://doi.org/10.1002/art.39067 PMID: 25779381. PMCID: PMC4523131.
The Road Traveled: Genomics and Biomarkers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Kimberly RP
Associated Clinical Trial(s):
Kimberly RP (2015). The Road Traveled: Genomics and Biomarkers in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol, 67(7), 1700-2. https://doi.org/10.1002/art.39148 PMID: 25891203.
Solving the puzzle of autoimmunity: critical questions
Smilek DE, St Clair EW
Associated Clinical Trial(s):
Smilek DE, St Clair EW (2015). Solving the puzzle of autoimmunity: critical questions. F1000Prime Rep, 7, 17. https://doi.org/10.12703/P7-17 PMID: 25750735. PMCID: PMC4335798.
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D
Associated Clinical Trial(s):
Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D (2015). Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun, 58, 48-58. https://doi.org/10.1016/j.jaut.2015.01.001 PMID: 25634360. PMCID: PMC8153751.
Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement
Geetha D, Specks U, Stone JH, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Tchao NK, Ikle D, Jepson B, Brunetta P, Fervenza FC, Rituximab for ANCA-Associated Vasculitis Immune Tolerance Network Research Group
Associated Clinical Trial(s):
Geetha D, Specks U, Stone JH, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Fessler BJ, Ding L, Tchao NK, Ikle D, Jepson B, Brunetta P, Fervenza FC, Rituximab for ANCA-Associated Vasculitis Immune Tolerance Network Research Group (2015). Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement. J Am Soc Nephrol, 26(4), 976-85. https://doi.org/10.1681/ASN.2014010046 PMID: 25381429. PMCID: PMC4378104.
Outcomes of nonsevere relapses in antineutrophil cytoplasmic antibody-associated vasculitis treated with glucocorticoids
Miloslavsky EM, Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Ding L, Iklé D, Villareal M, Lim N, Brunetta P, Fervenza FC, Monach PA, Stone JH, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group
Associated Clinical Trial(s):
Miloslavsky EM, Specks U, Merkel PA, Seo P, Spiera R, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Ding L, Iklé D, Villareal M, Lim N, Brunetta P, Fervenza FC, Monach PA, Stone JH, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group (2015). Outcomes of nonsevere relapses in antineutrophil cytoplasmic antibody-associated vasculitis treated with glucocorticoids. Arthritis Rheumatol, 67(6), 1629-36. https://doi.org/10.1002/art.39104 PMID: 25776953. PMCID: PMC5956529.
Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Grayson PC, Carmona-Rivera C, Xu L, Lim N, Gao Z, Asare AL, Specks U, Stone JH, Seo P, Spiera RF, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Ytterberg SR, Phippard DJ, Merkel PA, Kaplan MJ, Monach PA, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group
Associated Clinical Trial(s):
Grayson PC, Carmona-Rivera C, Xu L, Lim N, Gao Z, Asare AL, Specks U, Stone JH, Seo P, Spiera RF, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Tchao NK, Ytterberg SR, Phippard DJ, Merkel PA, Kaplan MJ, Monach PA, Rituximab in ANCA-Associated Vasculitis-Immune Tolerance Network Research Group (2015). Neutrophil-Related Gene Expression and Low-Density Granulocytes Associated With Disease Activity and Response to Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol, 67(7), 1922-32. https://doi.org/10.1002/art.39153 PMID: 25891759. PMCID: PMC4485551.
Peripheral CD5+ B cells in antineutrophil cytoplasmic antibody-associated vasculitis
Unizony S, Lim N, Phippard DJ, Carey VJ, Miloslavsky EM, Tchao NK, Iklé D, Asare AL, Merkel PA, Monach PA, Seo P, St Clair EW, Langford CA, Spiera R, Hoffman GS, Kallenberg CG, Specks U, Stone JH
Associated Clinical Trial(s):
Unizony S, Lim N, Phippard DJ, Carey VJ, Miloslavsky EM, Tchao NK, Iklé D, Asare AL, Merkel PA, Monach PA, Seo P, St Clair EW, Langford CA, Spiera R, Hoffman GS, Kallenberg CG, Specks U, Stone JH (2015). Peripheral CD5+ B cells in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheumatol, 67(2), 535-44. https://doi.org/10.1002/art.38916 PMID: 25332071. PMCID: PMC4497572.
High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim report
Nash RA, Hutton GJ, Racke MK, Popat U, Devine SM, Griffith LM, Muraro PA, Openshaw H, Sayre PH, Stüve O, Arnold DL, Spychala ME, McConville KC, Harris KM, Phippard D, Georges GE, Wundes A, Kraft GH, Bowen JD
Associated Clinical Trial(s):
Nash RA, Hutton GJ, Racke MK, Popat U, Devine SM, Griffith LM, Muraro PA, Openshaw H, Sayre PH, Stüve O, Arnold DL, Spychala ME, McConville KC, Harris KM, Phippard D, Georges GE, Wundes A, Kraft GH, Bowen JD (2015). High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim report. JAMA Neurol, 72(2), 159-69. https://doi.org/10.1001/jamaneurol.2014.3780 PMID: 25546364. PMCID: PMC5261862.
Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge
Scadding GW, Eifan AO, Lao-Araya M, Penagos M, Poon SY, Steveling E, Yan R, Switzer A, Phippard D, Togias A, Shamji MH, Durham SR
Associated Clinical Trial(s):
Scadding GW, Eifan AO, Lao-Araya M, Penagos M, Poon SY, Steveling E, Yan R, Switzer A, Phippard D, Togias A, Shamji MH, Durham SR (2015). Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge. Allergy, 70(6), 689-96. https://doi.org/10.1111/all.12608 PMID: 25773990. PMCID: PMC4826905.
Local and systemic effects of cat allergen nasal provocation
Scadding GW, Eifan A, Penagos M, Dumitru A, Switzer A, McMahon O, Phippard D, Togias A, Durham SR, Shamji MH
Associated Clinical Trial(s):
Scadding GW, Eifan A, Penagos M, Dumitru A, Switzer A, McMahon O, Phippard D, Togias A, Durham SR, Shamji MH (2015). Local and systemic effects of cat allergen nasal provocation. Clin Exp Allergy, 45(3), 613-23. https://doi.org/10.1111/cea.12434 PMID: 25303516. PMCID: PMC4778413.
Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response
Shamji MH, Layhadi JA, Scadding GW, Cheung DKM, Calderon MA, Turka LA, Phippard D, Durham SR
Associated Clinical Trial(s):
Shamji MH, Layhadi JA, Scadding GW, Cheung DKM, Calderon MA, Turka LA, Phippard D, Durham SR (2015). Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response. J Allergy Clin Immunol, 135(4), 913-921.e9. https://doi.org/10.1016/j.jaci.2014.09.049 PMID: 25457150.
Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals
Shamji MH, Bellido V, Scadding GW, Layhadi JA, Cheung DK, Calderon MA, Asare A, Gao Z, Turka LA, Tchao N, Togias A, Phippard D, Durham SR
Associated Clinical Trial(s):
Shamji MH, Bellido V, Scadding GW, Layhadi JA, Cheung DK, Calderon MA, Asare A, Gao Z, Turka LA, Tchao N, Togias A, Phippard D, Durham SR (2015). Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals. Allergy, 70(2), 171-9. https://doi.org/10.1111/all.12543 PMID: 25377909.
Randomized trial of peanut consumption in infants at risk for peanut allergy
Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G, LEAP Study Team
Associated Clinical Trial(s):
Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G, LEAP Study Team (2015). Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med, 372(9), 803-13. https://doi.org/10.1056/NEJMoa1414850 PMID: 25705822. PMCID: PMC4416404.
Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R
Associated Clinical Trial(s):
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R (2014). Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes, 63(7), 2402-14. https://doi.org/10.2337/db13-1775 PMID: 24550192.
High-throughput flow cytometry data normalization for clinical trials
Finak G, Jiang W, Krouse K, Wei C, Sanz I, Phippard D, Asare A, De Rosa SC, Self S, Gottardo R
Associated Clinical Trial(s):
Finak G, Jiang W, Krouse K, Wei C, Sanz I, Phippard D, Asare A, De Rosa SC, Self S, Gottardo R (2014). High-throughput flow cytometry data normalization for clinical trials. Cytometry A, 85(3), 277-86. https://doi.org/10.1002/cyto.a.22433 PMID: 24382714. PMCID: PMC3992339.
Targeted immune interventions for type 1 diabetes: not as easy as it looks!
Rigby MR, Ehlers MR
Associated Clinical Trial(s):
Rigby MR, Ehlers MR (2014). Targeted immune interventions for type 1 diabetes: not as easy as it looks! Curr Opin Endocrinol Diabetes Obes, 21(4), 271-8. https://doi.org/10.1097/MED.0000000000000075 PMID: 24983393. PMCID: PMC4133939.
Transplantation: moving to the next level
Sykes M
Associated Clinical Trial(s):
Sykes M (2014). Transplantation: moving to the next level. Immunol Rev, 258(1), 5-11. https://doi.org/10.1111/imr.12161 PMID: 24517422. PMCID: PMC4038030.