Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance
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Self-tolerance curtails the B cell repertoire to microbial epitopes
Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G
Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G (2019). Self-tolerance curtails the B cell repertoire to microbial epitopes. JCI Insight, 4 (10).
Disease Activity, ANCA-Type, and Lipid Levels in ANCA-Associated Vasculitis
Wallace ZS, Fu X, Liao K, Kallenberg CGM, Langford CA, Merkel PA, Monach P, Seo P, Specks U, Spiera R, St Clair EW, Zhang Y, Choi H, Stone JH
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The Association of Pulmonary Haemorrhage, Positive PR3-ANCA and Urinary Red Blood Cell Casts with Venous Thromboembolism in ANCA-Associated Vasculitis
Kronbichler A, Leierer J, Shin JI, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman M, Kallenberg CGM, St Clair EW, Brunetta P, Fervenza FC, Geetha D, Keogh KA, Monach PA, Ytterberg SR, Mayer G, Specks U, Stone JH, RAVE-ITN Research Group
Kronbichler A, Leierer J, Shin JI, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman M, Kallenberg CGM, St Clair EW, Brunetta P, Fervenza FC, Geetha D, Keogh KA, Monach PA, Ytterberg SR, Mayer G, Specks U, Stone JH, RAVE-ITN Research Group (2019). The Association of Pulmonary Haemorrhage, Positive PR3-ANCA and Urinary Red Blood Cell Casts with Venous Thromboembolism in ANCA-Associated Vasculitis. Arthritis Rheumatol., epub ahead of print.
The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis
Berti A, Warner RL, Johnson KJ, Cornec D, Schroeder DR, Kabat BF, Langford CA, Kallenberg CGM, Seo P, Spiera RF, St Clair EW, Fervenza FC, Stone JH, Monach PA, Specks U, Merkel PA, RAVE-ITN Research Group
Berti A, Warner RL, Johnson KJ, Cornec D, Schroeder DR, Kabat BF, Langford CA, Kallenberg CGM, Seo P, Spiera RF, St Clair EW, Fervenza FC, Stone JH, Monach PA, Specks U, Merkel PA, RAVE-ITN Research Group (2019). The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis. J Autoimmun, epub ahead of print.
Post-transplant biopsy risk for stable long-term pediatric liver transplant recipients: 451 percutaneous biopsies from two multi-center immunosuppression withdrawal trials
Perito ER, Martinez M, Turmelle YP, Mason K, Spain KM, Bucuvalas JC, Feng S
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Outcomes of immunosuppression minimization and withdrawal early after liver transplantation
Shaked A, DesMarais MR, Kopetskie H, Feng S, Punch J, Levitsky J, Reyes J, Klintmalm G, Demetris AJ, Burrell BE, Priore A, Bridges ND, Sayre PH
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Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring
Wood-Trageser MA, Lesniak A, Demetris AJ
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Transplantation tolerance in nonhuman primates and humans.
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T-cell exhaustion correlates with improved outcomes in kidney transplant recipients
Fribourg M, Anderson L, Fischman C, Cantarelli C, Perin L, La Manna G, Rahman A, Burrell BE, Heeger PS, Cravedi P
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IgG4 donor-specific HLA antibody profile is associated with subclinical rejection in stable pediatric liver recipients
Jackson AM, Kanaparthi S, Burrell BE, Lucas DP, Vega RM, Demetris AJ, Feng S
Jackson AM, Kanaparthi S, Burrell BE, Lucas DP, Vega RM, Demetris AJ, Feng S (2019). IgG4 donor-specific HLA antibody profile is associated with subclinical rejection in stable pediatric liver recipients. Am J Transplant, epub ahead of print.
Cell type–specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes
Dufort MJ, Greenbaum CJ, Speake C, Linsley PS
Dufort MJ, Greenbaum CJ, Speake C, Linsley PS (2019). Cell type–specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes. JCI Insight, 4 (4), e125556.
B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes
Linsley PS, Greenbaum CJ, Speake C, Long SA, Dufort MJ
Linsley PS, Greenbaum CJ, Speake C, Long SA, Dufort MJ (2019). B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes. JCI Insight, 4 (4), e126136.
Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression
Habib T, Long SA, Samuels PL, Brahmandam A, Tatum M, Funk A, Hocking AM, Cerosaletti K, Mason MT, Whalen E, Rawlings DJ, Greenbaum CJ, Buckner JH, the Type 1 Diabetes TrialNet Study Group
Habib T, Long SA, Samuels PL, Brahmandam A, Tatum M, Funk A, Hocking AM, Cerosaletti K, Mason MT, Whalen E, Rawlings DJ, Greenbaum CJ, Buckner JH, the Type 1 Diabetes TrialNet Study Group (2019). Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression. Diabetes, epub ahead of print.
Treg gene signatures predict and measure type 1 diabetes trajectory
Pesenacker AM, Chen V, Gillies J, Speake C, Marwaha AK, Sun A, Chow S, Tan R, Elliot T, Dutz JP, Tebbutt SJ, Levings MK
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Low-dose Anti-Thymocyte Globulin Preserves C-Peptide and Reduces A1c in New Onset Type 1 Diabetes: Two Year Clinical Trial Data
Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer J, Bundy BN, Geyer SM, Warnock MV, Miller J, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ, Type 1 Diabetes TrialNet ATG-GCSF Study Group
Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer J, Bundy BN, Geyer SM, Warnock MV, Miller J, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ, Type 1 Diabetes TrialNet ATG-GCSF Study Group (2019). Low-dose Anti-Thymocyte Globulin Preserves C-Peptide and Reduces A1c in New Onset Type 1 Diabetes: Two Year Clinical Trial Data. Diabetes, db190057.
Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes
Linsley PS, Greenbaum CJ, Rosasco M, Presnell S, Herold KC, Dufort MJ
Linsley PS, Greenbaum CJ, Rosasco M, Presnell S, Herold KC, Dufort MJ (2019). Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes. Genes Immun, 20 (4), 293-307.
Elicited and pre‐existing anti‐Neu5Gc antibodies differentially affect human endothelial cells transcriptome
Le Berre L, Danger R, Mai HL, Amon R, Leviatan Ben-Ayre S, Bruneau S, Senage T, Perreault H, Teraiya M, Nguyen TVH, Le Tourneau T, Yu H, Chen X, Galli C, Roussel JC, Manez R, Costa C, Brouard S, Galinanes, M, Harris KM, Gitelman S, Cozzi E, Charreau B, Padler-Karavani V, Soulillou JP
Le Berre L, Danger R, Mai HL, Amon R, Leviatan Ben-Ayre S, Bruneau S, Senage T, Perreault H, Teraiya M, Nguyen TVH, Le Tourneau T, Yu H, Chen X, Galli C, Roussel JC, Manez R, Costa C, Brouard S, Galinanes, M, Harris KM, Gitelman S, Cozzi E, Charreau B, Padler-Karavani V, Soulillou JP (2019). Elicited and pre‐existing anti‐Neu5Gc antibodies differentially affect human endothelial cells transcriptome. Xenotransplantation, epub ahead of print.
Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study.
Speake C, Bahnson HT, Wesley JD, Perdue N, Friedrich D, Pham MN, Lanxon-Cookson E, Kwok WW, Sehested Hanson B, von Herrath M, Greenbaum CJ
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A composite immune signature parallels disease progression across T1D subjects
Speake C, Skinner SO, Berel D, Whalen E, Dufort MJ, Young WC, Odegard JM, Pesenacker AM, Gorus FK, James E, Levings MK, Linsley PS, Akirav EM, Pugliese A, Hessner MJ, Nepom GT, Gottardo R, Long SA
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A novel human mast cell activation test for peanut allergy
Santos AF, Couto-Francisco N, Becares N, Kwok M, Bahnson HT, Lack G
Santos AF, Couto-Francisco N, Becares N, Kwok M, Bahnson HT, Lack G (2018). A novel human mast cell activation test for peanut allergy. J Allergy Clin Immunol, 142 (2), 689-691.
Food allergy
Renz H, Allen KJ, Sicherer SH, Sampson HA, Lack G, Beyer K, Oettgen HC
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Treatment for food allergy
Burks AW, Sampson HA, Plaut M, Lack G, Akdis C
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Mechanisms of food allergy
Sampson HA, O'Mahony, L. Burks, AW. Plaut, M. Lack, Akdis CA
Sampson HA, O'Mahony, L. Burks, AW. Plaut, M. Lack, Akdis CA (2018). Mechanisms of food allergy. J Allergy Clin Immunol, 141 (1), 11-19.
The challenges of preventing food allergy: Lessons learned from LEAP and EAT
Fisher HR, Du Toit G, Bahnson HT, Lack G
Fisher HR, Du Toit G, Bahnson HT, Lack G (2018). The challenges of preventing food allergy: Lessons learned from LEAP and EAT. Ann Allergy Asthma Immunol, 121 (3), 313-319.
Basophil Activation Test: Old and New Applications in Allergy
Hemmings O, Kwok M, McKendry R, Santos AF
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Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity
Harris KM, Lu T, Lim N, Turka LA
Harris KM, Lu T, Lim N, Turka LA (2018). Challenges and Opportunities for Biomarkers of Clinical Response to AHSCT in Autoimmunity. Front Immunol, 9, 100.
FRI0305 Phase 2 trial of induction therapy with anti-cd20 (RITUXIMAB) followed by maintenance therapy with anti-baff (BELIMUMAB) in patients with active lupus nephritis
Aranow C, Dall'Era M, Byron M, Ding L, Smilek D, Diamond B, Wofsy D
Aranow C, Dall'Era M, Byron M, Ding L, Smilek D, Diamond B, Wofsy D (2018). FRI0305 Phase 2 trial of induction therapy with anti-cd20 (RITUXIMAB) followed by maintenance therapy with anti-baff (BELIMUMAB) in patients with active lupus nephritis. Ann Rheum Dis, 690.
Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants
Feng S, Bucuvalas JC, Demetris AJ, Burrell BE, Spain KM, Kanaparthi S, Magee JC, Ikle D, Lesniak A, Lozano JJ, Alonso EM, Bray RA, Bridges NE, Doo E, Gebel HM, Gupta NA, Himes RW, Jackson AM, Lobritto SJ, Mazariegos GV, Ng VL, Rand EB, Sherker AH, Sundaram S, Turmelle YP, Sanchez-Fueyo A
Feng S, Bucuvalas JC, Demetris AJ, Burrell BE, Spain KM, Kanaparthi S, Magee JC, Ikle D, Lesniak A, Lozano JJ, Alonso EM, Bray RA, Bridges NE, Doo E, Gebel HM, Gupta NA, Himes RW, Jackson AM, Lobritto SJ, Mazariegos GV, Ng VL, Rand EB, Sherker AH, Sundaram S, Turmelle YP, Sanchez-Fueyo A (2018). Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants. Gastroenterology, E published ahead of print.
Early expansion of donor-specific Tregs in tolerant kidney transplant recipients
Savage TM, Shonts BA, Obradovic A, DeWolf S, Lau S, Zuber J, Simpson MT, Berglund E, Fu J, Yang S, Ho S, Tang Q, Turka LA, Shen Y, Sykes M
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